Approach
A drug discovery approach based on physiological regulation
Our company views biological functions, including saliva and tear secretion, as part of a physiologically precise system. Based on this understanding, we employ a drug discovery approach that leverages the body's natural signals rather than applying excessive stimulation or uniform effects.
Why
Physiological
Im Matters
Many biological functions maintain homeostasis through precise regulation within a certain range. Saliva and tear secretion are similar; they are not simply functions that respond to strong stimulation, but rather are expressed under physiological control, including time of day and individual differences. We believe that respecting this physiological control mechanism is crucial in treatment design.
Mechanism
of Action
In our drug discovery approach, we assume physiological signal transduction mediated by endogenous ligands and adopt a strategy focused on modulating and enhancing these signals.Through this design, we aim to leverage the body’s intrinsic regulatory mechanisms to elicit receptor functions involved in salivary secretion in a more natural and physiologically aligned manner.
Implications
for Drug Design
We believe that the approach of enhancing physiological signals is particularly significant in that it compensates for biological functions that have been weakened by aging or disease.
Designing a drug to act only when physiologically necessary makes it easier to balance therapeutic effects and side effects, potentially leading to treatment that takes into account individual differences and variations in remaining function.
We believe this approach can contribute to solving challenges in the medical field in an aging society.
Current Program
Our company is currently focusing on one main development program targeting xerostomia and dry eye. This program is
This approach aims to create new treatment options based on a drug discovery strategy rooted in physiological regulation.
Development Stage
This program is moving to the next development stage based on the knowledge gained so far in non-clinical and early clinical trials.
Currently, we consider clinical Proof of Concept (PoC) trials aimed at verifying efficacy as an important milestone.
Strategic Significance
This program aims to explore new treatment possibilities to address unmet medical needs that have not been adequately met.
Furthermore, we believe that the knowledge gained through this development will serve as an important foundation for future applications, including expanding the range of indications and exploring new drug discovery themes.
Designing a drug to act only when physiologically necessary makes it easier to balance therapeutic effects and side effects, potentially leading to treatment that takes into account individual differences and variations in remaining function.
We believe this approach can contribute to solving challenges in the medical field in an aging society.